It is the widest antibacterial among the aminoglycosides. It has resistance to the enzymes that inactivate aminoglycosides. It is derived from Kanamycin.
Route – It is given by injection through intramuscular route and intravenous route.
Dose :–
In adults: 15 mg. per kilogram daily, in two equal divided doses, for 10 days.
In children: 15 mg per kilogram daily, in three divided doses, every 8 hours.
Indications – Respiratory Tract Infection, Bone and Joints Infection, Meningitis, Central Nervous System Infection, Skin and Soft Tissue Infection, Intra-abdominal Infection, Peritonitis, Burns, Post Operative Infection, Bacteria, Septicemia.
Contraindications – Hypersensitivity, Pregnancy, Ear drum perforation, Severe myasthenia gravis.
Interactions – Similar to gentamicin or similar to streptomycin.
Adverse effects/Side effects – Hypersensitivity reaction, nausea, vomiting, nephrotoxicity, ototoxicity, head-ache, vertigo, ataxia, neuro-muscular blockade.
Brand Names – Inj Mikacin 100 mg, 250 mg, 500 mg: Inj Vimicin 125 mg, 250 mg, 500 mg; Inj Amistar 100 mg, 250 mg, 500 mg; Inj Ametax 100 mg, 250 mg, 500 mg |